Novel heterozygous ABCB4 gene mutation causing recurrent first-trimester intrahepatic cholestasis of pregnancy
نویسندگان
چکیده
منابع مشابه
ONLINE MUTATION REPORT ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is a liver disease of pregnancy that complicates 0.7% of pregnancies in the UK. 2 ICP causes maternal pruritus and hepatic impairment and can cause fetal death, spontaneous prematurity, and sudden intrauterine death. A diagnosis of ICP is made by the demonstration of abnormal liver function test results, and in pa...
متن کاملSevere First Trimester Recurrent Intrahepatic Cholestasis of Pregnancy: A Case Report and Literature Review
Background Intrahepatic cholestasis of pregnancy (ICP) is a disorder of defective bile acid transport that results in systemic accumulation of bile acids and typically presents in the third trimester of pregnancy with intense pruritus. A positive linear correlation exists between total bile acid level and poor pregnancy outcome, and labor is typically induced at 37 weeks gestation to prevent in...
متن کاملABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is a liver disease of pregnancy that complicates 0.7% of pregnancies in the UK. 2 ICP causes maternal pruritus and hepatic impairment and can cause fetal death, spontaneous prematurity, and sudden intrauterine death. A diagnosis of ICP is made by the demonstration of abnormal liver function test results, and in pa...
متن کاملIntrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spon...
متن کاملRecurrent intrahepatic cholestasis of pregnancy. A case report.
Intrahepatic cholestasis of pregnancy (ICP) represents a rare but severe pathology with serious consequences on the outcome of pregnancy. We present the cases of two sisters that came to our clinic with ICP in successive pregnancies. The fetus from a pregnancy with cholestasis can be affected by preterm birth, respiratory distress syndrome, intrauterine death in the third trimester and a possib...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2014
ISSN: 0743-8346,1476-5543
DOI: 10.1038/jp.2014.86